Compounds > 5-methyl-2-[[(4-nitrophenyl)-oxomethyl]hydrazo]-4-thiazolecarboxylic acid ethyl ester
Page last updated: 2024-08-01 02:43:48

5-methyl-2-[[(4-nitrophenyl)-oxomethyl]hydrazo]-4-thiazolecarboxylic acid ethyl ester

Description

5-methyl-2-[[(4-nitrophenyl)-oxomethyl]hydrazo]-4-thiazolecarboxylic acid ethyl ester : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID3815079
CHEMBL ID1419381
CHEBI ID105090

Synonyms (19)

Synonym
smr000502259
MLS001181095
STK104500
ethyl 5-methyl-2-{2-[(4-nitrophenyl)carbonyl]hydrazinyl}-1,3-thiazole-4-carboxylate
CHEBI:105090
AKOS001039631
ethyl 5-methyl-2-[2-(4-nitrobenzoyl)hydrazinyl]-1,3-thiazole-4-carboxylate
HMS2817K15
REGID_FOR_CID_3815079
CHEMBL1419381
ethyl 5-methyl-2-[(4-nitrophenyl)hydrazido]-1,3-thiazole-4-carboxylate
Q27182775
5-methyl-2-[[(4-nitrophenyl)-oxomethyl]hydrazo]-4-thiazolecarboxylic acid ethyl ester
SR-01000290755-1
sr-01000290755
524057-11-2
DTXSID201157060
ethyl 5-methyl-2-[2-(4-nitrobenzoyl)hydrazinyl]-4-thiazolecarboxylate
Z56895370

Drug Classes (1)

ClassDescription
C-nitro compoundA nitro compound having the nitro group (-NO2) attached to a carbon atom.

Protein Targets (24)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency50.1187AID504339
glp-1 receptor, partialHomo sapiens (human)Potency28.1838AID624417
ATAD5 protein, partialHomo sapiens (human)Potency16.3535AID504467
TDP1 proteinHomo sapiens (human)Potency17.5886AID686978; AID686979
thioredoxin glutathione reductaseSchistosoma mansoniPotency7.9433AID485364
Smad3Homo sapiens (human)Potency22.3872AID588855
apical membrane antigen 1, AMA1Plasmodium falciparum 3D7Potency3.1623AID720542
PINK1Homo sapiens (human)Potency50.1187AID624263
67.9K proteinVaccinia virusPotency12.9676AID720579; AID720580
ParkinHomo sapiens (human)Potency50.1187AID624263
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency44.6684AID504333
IDH1Homo sapiens (human)Potency9.2000AID686970
euchromatic histone-lysine N-methyltransferase 2Homo sapiens (human)Potency44.6684AID504332
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency50.1187AID2100
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency5.6234AID485313
nuclear factor erythroid 2-related factor 2 isoform 2Homo sapiens (human)Potency23.1093AID504444
ras-related protein Rab-9AHomo sapiens (human)Potency3.5481AID485297
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency3.3782AID2546; AID2551
gemininHomo sapiens (human)Potency3.6626AID624297
muscleblind-like protein 1 isoform 1Homo sapiens (human)Potency11.2202AID2675
Guanine nucleotide-binding protein GHomo sapiens (human)Potency50.1187AID624287; AID624288
TAR DNA-binding protein 43Homo sapiens (human)Potency12.5893AID652104

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
high affinity choline transporter 1 isoform aHomo sapiens (human)IC509.9147AID504840

Activation Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
heat shock protein 90Candida albicansEC500.9810AID2423

Bioassays (7)

Assay IDTitleYearJournalArticle
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
dinitrochlorobenzene
0
C-nitro compound;
monochlorobenzenes		allergen;
epitope;
sensitiser		00low000000
levoplast
0
C-nitro compound00low000000
4-nitrobenzaldehyde
0
benzaldehydes;
C-nitro compound		00low000000
parathion
0
C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
mouse metabolite		00low000000
3-nitropropionic acid
0
C-nitro compoundantimycobacterial drug;
EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor;
mycotoxin;
neurotoxin		00low000000
aristolochic acid i
0
aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin		00low000000
azathioprine
0
aryl sulfide;
C-nitro compound;
imidazoles;
thiopurine		antimetabolite;
antineoplastic agent;
carcinogenic agent;
DNA synthesis inhibitor;
hepatotoxic agent;
immunosuppressive agent;
prodrug		00low000000
bay-k-8644
0
(trifluoromethyl)benzenes;
C-nitro compound;
dihydropyridine;
methyl ester		00low000000
benefin
0
C-nitro compound;
organofluorine compound;
substituted aniline;
tertiary amino compound		agrochemical;
herbicide		00low000000
dimetridazole
0
C-nitro compound;
imidazoles		antiparasitic agent;
antiprotozoal drug		00low000000
etanidazole
0
C-nitro compound;
imidazoles;
monocarboxylic acid amide		alkylating agent;
antineoplastic agent;
prodrug;
radiosensitizing agent		00low000000
flunitrazepam
0
1,4-benzodiazepinone;
C-nitro compound;
monofluorobenzenes		anxiolytic drug;
GABAA receptor agonist;
sedative		00low000000
methyl parathion
0
C-nitro compound;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
genotoxin		00low000000
metronidazole
0
C-nitro compound;
imidazoles;
primary alcohol		antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic		00low000000
nicardipine
0
benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound		00low000000
niclosamide
0
benzamides;
C-nitro compound;
monochlorobenzenes;
salicylanilides;
secondary carboxamide		anthelminthic drug;
anticoronaviral agent;
antiparasitic agent;
apoptosis inducer;
molluscicide;
piscicide;
STAT3 inhibitor		00low000000
nifedipine
0
C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent		00low000000
nilutamide
0
(trifluoromethyl)benzenes;
C-nitro compound;
imidazolidinone		androgen antagonist;
antineoplastic agent		00low000000
nimesulide
0
aromatic ether;
C-nitro compound;
sulfonamide		cyclooxygenase 2 inhibitor;
non-steroidal anti-inflammatory drug		00low000000
nimetazepam
0
1,4-benzodiazepinone;
C-nitro compound		anticonvulsant;
antispasmodic drug;
GABA modulator;
sedative		00low000000
nimodipine
0
2-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester		antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent		00low000000
nisoldipine
0
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
methyl ester		00low000000
nitrazepam
0
1,4-benzodiazepinone;
C-nitro compound		anticonvulsant;
antispasmodic drug;
drug metabolite;
GABA modulator;
sedative		00low000000
nitrendipine
0
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
ethyl ester;
methyl ester		antihypertensive agent;
calcium channel blocker;
geroprotector;
vasodilator agent		00low000000
nizatidine
0
1,3-thiazoles;
C-nitro compound;
carboxamidine;
organic sulfide;
tertiary amino compound		anti-ulcer drug;
cholinergic drug;
H2-receptor antagonist		00low000000
n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide
0
aromatic ether;
C-nitro compound;
sulfonamide		antineoplastic agent;
cyclooxygenase 2 inhibitor		00low000000
oxamniquine
0
aromatic primary alcohol;
C-nitro compound;
quinolines;
secondary amino compound		00low000000
4-nitrophenylacetic acid
0
C-nitro compound;
phenylacetic acids		00low000000
ronidazole
0
C-nitro compound;
carbamate ester;
imidazoles		antiparasitic agent;
antiprotozoal drug		00low000000
trifluralin
0
(trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide;
xenobiotic		00low000000
4-nitroquinoline-1-oxide
0
C-nitro compound;
quinoline N-oxide		carcinogenic agent00low000000
chloramphenicol
0
C-nitro compound;
carboxamide;
diol;
organochlorine compound		antibacterial drug;
antimicrobial agent;
Escherichia coli metabolite;
geroprotector;
Mycoplasma genitalium metabolite;
protein synthesis inhibitor		00low000000
niridazole
0
1,3-thiazoles;
C-nitro compound		00low000000
dinitrofluorobenzene
0
C-nitro compound;
organofluorine compound		agrochemical;
allergen;
chromatographic reagent;
EC 2.7.3.2 (creatine kinase) inhibitor;
protein-sequencing agent;
spectrophotometric reagent		00low000000
nifenalol
0
C-nitro compound00low000000
chloropicrin
0
C-nitro compound;
one-carbon compound;
organochlorine compound		antifungal agrochemical;
fumigant insecticide;
nematicide		00low000000
quintozene
0
aromatic fungicide;
C-nitro compound;
pentachlorobenzenes		antifungal agrochemical00low000000
musk ambrette (artificial)
0
C-nitro compound00low000000
1-chloro-2-nitrobenzene
0
C-nitro compound;
monochlorobenzenes		00low000000
picryl chloride
0
C-nitro compound;
monochlorobenzenes		allergen;
epitope;
explosive;
hapten		00low000000
picric acid
0
C-nitro compoundantiseptic drug;
explosive;
fixative		00low000000
2,4-dinitrobenzenesulfonic acid
0
arenesulfonic acid;
C-nitro compound		00low000000
2-nitro-4-methylaniline
0
C-nitro compound00low000000
3,5-dinitrobenzoic acid
0
benzoic acids;
C-nitro compound		00low000000
5-nitro-2-toluidine
0
C-nitro compound00low000000
4-chloronitrobenzene
0
C-nitro compound00low000000
4-nitrobenzyl chloride
0
benzyl chlorides;
C-nitro compound		mutagen00low000000
4-nitroacetophenone
0
acetophenones;
C-nitro compound		00low000000
tecnazene
0
aromatic fungicide;
C-nitro compound;
tetrachlorobenzene		antifungal agrochemical00low000000
4-amino-2-nitrotoluene
0
C-nitro compound00low000000
2-amino-5-nitrothiazole
0
C-nitro compound;
thiazoles		00low000000
naphthol yellow
0
C-nitro compound;
naphthalenesulfonic acid;
naphthols		histological dye00low000000
azomycin
0
C-nitro compound;
imidazoles		antitubercular agent00low000000
trinitrobenzenesulfonic acid
0
arenesulfonic acid;
C-nitro compound		epitope;
explosive;
reagent		00low000000
2-nitrobenzaldehyde
0
benzaldehydes;
C-nitro compound		00low000000
1-bromo-2,4-dinitrobenzene
0
C-nitro compound;
organobromine compound		00low000000
3,5-dinitrosalicylic acid
0
C-nitro compound;
monohydroxybenzoic acid		hapten00low000000
3,5-dinitrotoluene
0
C-nitro compound00low000000
2-methyl-5-nitroimidazole
0
C-nitro compound;
imidazoles		00low000000
5-nitro-2-furaldehyde
0
C-nitro compound;
furans		00low000000
4-nitrophenyl acetate
0
C-nitro compound;
phenyl acetates		00low000000
methylparaoxon
0
C-nitro compound00low000000
dinobuton
0
C-nitro compound00low000000
pyrrolnitrin
0
alkaloid;
C-nitro compound;
monochlorobenzenes;
pyrroles		antifungal drug;
bacterial metabolite		00low000000
dinoterb
0
C-nitro compound;
phenols		00low000000
2,4-dinitrothiocyanatobenzene
0
C-nitro compound;
thiocyanates		hapten;
tolerogen		00low000000
2,4,6-trichlorophenyl 4-nitrophenyl ether
0
aromatic ether;
C-nitro compound;
chlorobenzenes		EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
n-methylamino-2-nitro-4-n',n'-bis(2-hydroxyethyl)aminobenzene
0
C-nitro compound00low000000
4-nitroimidazole
0
C-nitro compound;
imidazoles		00low000000
2-(alpha-thenoylamino)-2-nitro-5-thiazole
0
1,3-thiazoles;
C-nitro compound		00low000000
nitroxoline
0
C-nitro compound;
monohydroxyquinoline		antifungal agent;
antiinfective agent;
antimicrobial agent;
renal agent		00low000000
nitralin
0
C-nitro compound00low000000
1,2-epoxy-3-(p-nitrophenoxy)propane
0
aromatic ether;
C-nitro compound;
epoxide		00low000000
nimorazole
0
C-nitro compound;
imidazoles		00low000000
4-chloro-7-nitrobenzofurazan
0
benzoxadiazole;
C-nitro compound;
organochlorine compound		EC 1.4.3.4 (monoamine oxidase) inhibitor;
EC 3.6.1.3 (adenosinetriphosphatase) inhibitor;
fluorescent probe;
fluorochrome		00low000000
ipronidazole
0
C-nitro compound;
imidazoles		00low000000
ornidazole
0
C-nitro compound;
imidazoles;
organochlorine compound;
secondary alcohol		antiamoebic agent;
antibacterial drug;
antiinfective agent;
antiprotozoal drug;
antitrichomonal drug;
epitope		00low000000
oryzalin
0
aromatic amine;
C-nitro compound;
sulfonamide;
tertiary amino compound		agrochemical;
antimitotic;
herbicide		00low000000
fenitrothion
0
C-nitro compound;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide		00low000000
benzonidazole
0
C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug00low000000
N-(3-methyl-1,1-dioxo-1,4-thiazinan-4-yl)-1-(5-nitro-2-furanyl)methanimine
0
C-nitro compound;
furans		00low000000
3-nitro-1-propanol
0
C-nitro compound00low000000
amoscanate
0
C-nitro compound;
isothiocyanate;
secondary amino compound		schistosomicide drug00low000000
profluralin
0
C-nitro compound00low000000
dinitramine
0
C-nitro compound00low000000
hc blue no. 2
0
C-nitro compound00low000000
fluchloralin
0
C-nitro compound00low000000
butralin
0
C-nitro compound00low000000
isopropalin
0
C-nitro compound00low000000
pendimethalin
0
C-nitro compound;
secondary amino compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide		00low000000
ethafluralin
0
C-nitro compound00low000000
acifluorfen
0
aromatic ether;
benzoic acids;
C-nitro compound;
monocarboxylic acid;
organochlorine compound;
organofluorine compound		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
bromethalin
0
C-nitro compound00low000000
fomesafen
0
aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-sulfonylcarboxamide;
organofluorine compound;
phenols		agrochemical;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
bmy 25067
0
C-nitro compound;
organic disulfide		antineoplastic agent00low000000
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
0
C-nitro compound;
furans		00low000000
musk xylene
0
C-nitro compoundcarcinogenic agent;
explosive;
fragrance		00low000000
4-nitrophenylalanine
0
C-nitro compound00low000000
4-nitrobenzyl bromide
0
benzyl bromides;
C-nitro compound		allergen;
sensitiser		00low000000
nitarsone
0
C-nitro compound;
organoarsonic acid		agrochemical;
antiprotozoal drug		00low000000
5'-nitro-2'-propoxyacetanilide
0
aromatic ether;
C-nitro compound		00low000000
cinitapride
0
aromatic ether;
C-nitro compound		00low000000
5-nitrouracil
0
C-nitro compound00low000000
3-nitrobenzyl alcohol
0
C-nitro compound00low000000
4-nitrobenzyl alcohol
0
benzyl alcohols;
C-nitro compound		xenobiotic metabolite00low000000
secnidazole
0
C-nitro compound;
imidazoles;
secondary alcohol		epitope00low000000
4-nitrophenyl palmitate
0
C-nitro compound;
hexadecanoate ester		00low000000
4-nitrophenyl butyrate
0
butyrate ester;
C-nitro compound		00low000000
2-nitrophenylacetic acid
0
C-nitro compound;
phenylacetic acids		00low000000
4-nitrophenyl sulfate
0
aryl sulfate;
C-nitro compound		human metabolite00low000000
4-nitrophenyl-alpha-l-fucoside
0
alpha-L-fucoside;
C-nitro compound		chromogenic compound00low000000
4-nitrophenylglucuronide
0
beta-D-glucosiduronic acid;
C-nitro compound		chromogenic compound00low000000
chloramphenicol stearate
0
C-nitro compound00low000000
4,5-dimethoxy-2-nitrobenzaldehyde
0
aromatic ether;
C-nitro compound		00low000000
4-nitrophenyl beta-d-xyloside
0
C-nitro compound;
xyloside		chromogenic compound00low000000
fluazinam
0
(trifluoromethyl)benzenes;
aminopyridine;
C-nitro compound;
chloropyridine;
monochlorobenzenes;
secondary amino compound		allergen;
antifungal agrochemical;
apoptosis inducer;
environmental contaminant;
xenobiotic		00low000000
2-nitropropanol
0
C-nitro compound00low000000
aclonifen
0
aromatic ether;
C-nitro compound;
monochlorobenzenes;
primary amino compound;
substituted aniline		agrochemical;
carotenoid biosynthesis inhibitor;
EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide		00low000000
4-nitrophenyl beta-d-glucoside
0
beta-D-glucoside;
C-nitro compound		chromogenic compound00low000000
4-nitrophenyl alpha-glucoside
0
alpha-D-glucoside;
C-nitro compound;
monosaccharide derivative		chromogenic compound00low000000
bnps-skatole
0
aryl sulfide;
bromoindole;
C-nitro compound		reagent00low000000
nitrophenylgalactosides
0
beta-D-galactoside;
C-nitro compound		chromogenic compound00low000000
6-n-(2,4-dinitrophenyl)aminohexanoic acid
0
C-nitro compound00low000000
5-nitro-2-(1-piperidinyl)pyridine
0
C-nitro compound00low000000
s-(4-nitrobenzyl)glutathione
0
C-nitro compound;
organic sulfide;
S-substituted glutathione		00low000000
4-nitrophenyl-2-acetamido-2-deoxy-beta-d-glucopyranoside
0
C-nitro compound;
N-acetyl-beta-D-glucosaminide		chromogenic compound00low000000
miserotoxin
0
beta-D-glucoside;
C-nitro compound		phytotoxin00low000000
aristolochic acid ii
0
aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin		00low000000
nitisinone
0
(trifluoromethyl)benzenes;
C-nitro compound;
cyclohexanones;
mesotrione		EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor00low000000
efonidipine
0
C-nitro compound;
carboxylic ester;
dihydropyridine;
tertiary amino compound		00low000000
1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole
0
C-nitro compound;
imidazoles		00low000000
pyrrolomycin a
0
antibiotic antifungal agent;
C-nitro compound;
organochlorine compound;
pyrroles		antibacterial agent;
bacterial metabolite		00low000000
2,8-dinitroimipramine
0
C-nitro compound;
dibenzoazepine;
tertiary amino compound		00low000000
7-nitrobenzoxadiazole-6-aminohexanoic acid
0
benzoxadiazole;
C-nitro compound;
epsilon-amino acid;
secondary amino compound		fluorochrome00low000000
aristolochic acid D
0
aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
nephrotoxin;
toxin		00low000000
ag 3-5
0
C-nitro compound00low000000
thymidine 5'-4-nitrophenyl phosphate
0
aryl phosphate;
C-nitro compound;
pyrimidine 2'-deoxyribonucleoside 5'-monophosphate		00low000000
aristolochic acid c
0
aristolochic acids;
aromatic ether;
C-nitro compound;
cyclic acetal;
monocarboxylic acid;
organic heterotetracyclic compound		carcinogenic agent;
metabolite;
mutagen;
nephrotoxin;
toxin		00low000000
mesotrione
0
aromatic ketone;
beta-triketone;
C-nitro compound;
sulfone		carotenoid biosynthesis inhibitor;
EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor;
environmental contaminant;
herbicide;
xenobiotic		00low000000
3-nitrotyrosine
0
2-nitrophenols;
C-nitro compound;
nitrotyrosine;
non-proteinogenic alpha-amino acid		00low000000
4-[4-(3-methyl-4-nitrophenoxy)butoxy]benzonitrile
0
aromatic ether;
C-nitro compound		00low000000
N-(4-nitrophenyl)-2-phenoxyacetamide
0
C-nitro compound00low000000
rubitecan
0
C-nitro compound;
delta-lactone;
pyranoindolizinoquinoline;
semisynthetic derivative;
tertiary alcohol		antineoplastic agent;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
prodrug		00low000000
2-(3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole
0
C-nitro compound00low000000
7-nitro-5-indeno[1,2-b]pyridinone
0
C-nitro compound00low000000
5-(4-nitrophenyl)-4-phenyl-2-thiazolamine
0
C-nitro compound00low000000
N1-(4H-1,2,4-triazol-4-yl)-4-nitrobenzamide
0
C-nitro compound00low000000
2-methoxy-4-[(4-methyl-1,4-diazepan-1-yl)methyl]-6-nitrophenol
0
aromatic ether;
C-nitro compound		00low000000
N-(6-methyl-2-pyridinyl)-5-nitro-2-furancarboxamide
0
C-nitro compound;
furans		00low000000
(3,5-dimethyl-1-pyrazolyl)-(2-ethyl-4-nitro-3-pyrazolyl)methanone
0
C-nitro compound00low000000
N-(4-methyl-2-pyridinyl)-5-nitro-2-furancarboxamide
0
C-nitro compound;
furans		00low000000
4,5-dimethyl-2-[4-(3-nitrophenyl)-2-thiazolyl]-1H-pyrazol-3-one
0
C-nitro compound00low000000
N-methyl-2-[[4-methyl-5-[(4-nitrophenoxy)methyl]-1,2,4-triazol-3-yl]thio]acetamide
0
aromatic ether;
C-nitro compound		00low000000
N-[2-(4-fluorophenyl)ethyl]-4-nitrobenzamide
0
C-nitro compound00low000000
N-(2-fluoro-5-nitrophenyl)-2,2-dimethylbutanamide
0
C-nitro compound00low000000
3-(2-methoxyphenyl)-6-(3-nitrophenyl)-1,4-dihydropyrimidin-2-one
0
C-nitro compound00low000000
3-ethyl-6-(4-nitrophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
0
C-nitro compound00low000000
5-hydroxy-7-(4-nitrophenyl)-1,3-benzoxathiol-2-one
0
C-nitro compound00low000000
1-(3,4-dimethoxyphenyl)-3-(2-methoxy-5-nitrophenyl)urea
0
aromatic ether;
C-nitro compound		00low000000
N-(1-ethyl-2-benzimidazolyl)-5-[(4-methyl-2-nitrophenoxy)methyl]-2-furancarboxamide
0
aromatic ether;
C-nitro compound		00low000000
2-[[cyclohexyl(oxo)methyl]amino]-4-(3-nitrophenyl)-3-thiophenecarboxylic acid ethyl ester
0
C-nitro compound00low000000
1-(3-methoxy-5-nitrophenyl)-3-(4-methylphenyl)urea
0
aromatic ether;
C-nitro compound		00low000000
N-(5-tert-butyl-3-isoxazolyl)-3-nitrobenzamide
0
C-nitro compound00low000000
2-[[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]thio]-N-(2-pyridinyl)acetamide
0
C-nitro compound00low000000
N-(2-methyl-5-nitrophenyl)-4,6-bis(1-pyrrolidinyl)-1,3,5-triazin-2-amine
0
C-nitro compound00low000000
4-methoxy-N-[5-(4-methoxyphenyl)-4-(4-nitrophenyl)-2-thiazolyl]benzamide
0
C-nitro compound00low000000
4-methyl-2-(4-nitrophenyl)-5-thiazolecarboxylic acid
0
C-nitro compound00low000000
5-carbamoyl-4-methyl-2-[[(3-nitrophenyl)-oxomethyl]amino]-3-thiophenecarboxylic acid methyl ester
0
C-nitro compound00low000000
4-(3,5-dimethyl-4-nitro-1-pyrazolyl)butanoic acid
0
C-nitro compound00low000000
1-(3-fluorophenyl)-4-(4-hydroxy-3-methoxy-5-nitrophenyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester
0
aromatic ether;
C-nitro compound		00low000000
N-[5-(4-methoxyphenyl)-4-(4-nitrophenyl)-2-thiazolyl]-4-methylbenzamide
0
C-nitro compound00low000000
1,3-dimethyl-5-[[2-[2-(4-nitrophenoxy)ethoxy]phenyl]methylidene]-1,3-diazinane-2,4,6-trione
0
aromatic ether;
C-nitro compound		00low000000
stattic
0
1-benzothiophenes;
C-nitro compound;
sulfone		antineoplastic agent;
radiosensitizing agent;
STAT3 inhibitor		00low000000
2-fluoro-N-[2,2,2-trichloro-1-[[(4-methoxy-2-nitroanilino)-sulfanylidenemethyl]amino]ethyl]acetamide
0
aromatic ether;
C-nitro compound		00low000000
2-amino-4-(4,5-dimethoxy-2-nitrophenyl)-7,7-dimethyl-5-oxo-6,8-dihydro-4H-1-benzopyran-3-carbonitrile
0
aromatic ether;
C-nitro compound		00low000000
2,4-dichloro-N-[2,2,2-trichloro-1-[[(4-methoxy-2-nitroanilino)-sulfanylidenemethyl]amino]ethyl]benzamide
0
aromatic ether;
C-nitro compound		00low000000
N2-tert-butyl-6-ethoxy-N4-(4-nitrophenyl)-1,3,5-triazine-2,4-diamine
0
C-nitro compound00low000000
N-[4-methyl-5-[2-(3-nitroanilino)-4-thiazolyl]-2-thiazolyl]acetamide
0
C-nitro compound00low000000
2-methyl-N-[5-(4-nitrophenyl)sulfonyl-2-thiazolyl]pentanamide
0
C-nitro compound00low000000
N-[(2-ethyl-1-piperidinyl)-sulfanylidenemethyl]-4-nitrobenzamide
0
C-nitro compound00low000000
4-[[3-methoxy-4-[(4-nitrophenyl)methoxy]phenyl]-(3-methyl-5-oxo-1,2-dihydropyrazol-4-yl)methyl]-5-methyl-1,2-dihydropyrazol-3-one
0
C-nitro compound00low000000
N-(4-chloro-3-nitrophenyl)-3-phenylbutanamide
0
C-nitro compound00low000000
3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzene
0
C-nitro compound;
sulfonamide;
toluenes		bone density conservation agent;
EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor;
geroprotector		00low000000
2-[(4-chlorophenyl)sulfonyl-methylamino]-N-(4-methoxy-2-nitrophenyl)acetamide
0
aromatic ether;
C-nitro compound		00low000000
1-(2-fluorophenyl)-3-(4-methoxy-2-nitrophenyl)urea
0
aromatic ether;
C-nitro compound		00low000000
5-(2-nitrophenyl)-N-(2-thiazolyl)-2-furancarboxamide
0
C-nitro compound00low000000
ranitidine
0
C-nitro compound;
furans;
organic sulfide;
tertiary amino compound		anti-ulcer drug;
drug allergen;
environmental contaminant;
H2-receptor antagonist;
xenobiotic		00low000000
carnidazole
0
C-nitro compound;
imidazoles		00low000000
3-chloro-N-[2,2,2-trichloro-1-[[(4-methoxy-2-nitroanilino)-sulfanylidenemethyl]amino]ethyl]benzamide
0
aromatic ether;
C-nitro compound		00low000000
N-methyl-5-nitro-N-(phenylmethyl)-2-furancarboxamide
0
C-nitro compound;
furans		00low000000
3-nitro-N'-(2,4,6-trichlorophenyl)benzohydrazide
0
C-nitro compound00low000000
2-(2,2-dimethyl-4-oxanyl)-4-(4-nitrophenyl)thiazole
0
C-nitro compound00low000000
5-methyl-N-(3-methylphenyl)-4-nitro-1H-pyrazol-3-amine
0
C-nitro compound00low000000
3-nitro-N-[(1-oxopentylhydrazo)-sulfanylidenemethyl]benzamide
0
C-nitro compound00low000000
N-[[[2-(2-methylphenoxy)-1-oxoethyl]hydrazo]-sulfanylidenemethyl]-2-nitrobenzamide
0
C-nitro compound00low000000
N-(4-fluorophenyl)-5-nitro-2-pyridinamine
0
C-nitro compound00low000000
2-(4-chlorophenoxy)-N-(5-nitro-2-thiazolyl)acetamide
0
C-nitro compound;
thiazoles		00low000000
3-methyl-4-nitro-N-(1H-1,2,4-triazol-5-yl)benzamide
0
C-nitro compound00low000000
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-(1-phenylethylamino)ethyl] ester
0
C-nitro compound;
thiophenes		00low000000
2-[(5-amino-1H-1,2,4-triazol-3-yl)thio]-N-(2-bromo-4-nitrophenyl)acetamide
0
C-nitro compound00low000000
4-nitrophenylhydrazine
0
C-nitro compound;
phenylhydrazines		mutagen00low000000
4-(1-azepanyl)-6-hydrazinyl-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
0
C-nitro compound00low000000
2-amino-7-methyl-4-(5-nitro-2-furanyl)-5-oxo-4H-pyrano[3,2-c]pyran-3-carbonitrile
0
C-nitro compound;
furans		00low000000
N4-(1,1-dioxo-3-thiolanyl)-5-nitropyrimidine-4,6-diamine
0
C-nitro compound00low000000
N4-(3-chlorophenyl)-N2-methyl-5-nitropyrimidine-2,4,6-triamine
0
C-nitro compound00low000000
4-nitrocatechol
0
C-nitro compound;
catechols		human xenobiotic metabolite;
lipoxygenase inhibitor		00low000000
1-(1-naphthalenyl)-3-[[2-(2-nitrophenoxy)-1-oxoethyl]amino]urea
0
aromatic ether;
C-nitro compound		00low000000
nefurthiazole
0
C-nitro compound;
furans		00low000000
N-[5-(2,3-dihydro-1,4-dioxin-5-yl)-1,3,4-oxadiazol-2-yl]-5-nitro-2-thiophenecarboxamide
0
C-nitro compound;
thiophenes		00low000000
2-[(4-aminophenyl)thio]-N-(3-nitrophenyl)acetamide
0
C-nitro compound00low000000
3-[4-(2-hydroxyethylamino)-3-nitrophenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
0
C-nitro compound00low000000
2-[[6-amino-2-(3-methylanilino)-5-nitro-4-pyrimidinyl]amino]ethanol
0
C-nitro compound00low000000
N4-(3-fluorophenyl)-N2-[3-(4-morpholinyl)propyl]-5-nitropyrimidine-2,4,6-triamine
0
C-nitro compound00low000000
3-nitro-N-(2-phenylethyl)-2-pyridinamine
0
C-nitro compound00low000000
2-(4-nitrophenyl)-4-thiazolecarboxylic acid ethyl ester
0
C-nitro compound00low000000
N-(4-bromophenyl)-5-methyl-4-nitro-1H-pyrazol-3-amine
0
C-nitro compound00low000000
2,4-dinitrophenylhydrazine
0
C-nitro compound;
phenylhydrazines		reagent00low000000
3-methyl-N-[[[(4-nitrophenyl)-oxomethyl]hydrazo]-sulfanylidenemethyl]butanamide
0
C-nitro compound00low000000
N-(2-chlorophenyl)-4-[[(2-methoxy-4-nitroanilino)-sulfanylidenemethyl]hydrazo]-4-oxobutanamide
0
aromatic ether;
C-nitro compound		00low000000
5-nitro-2-thiophenecarboxylic acid [1-[(3,5-dichloro-2-pyridinyl)amino]-1-oxopropan-2-yl] ester
0
C-nitro compound;
thiophenes		00low000000
N-[2-[(4-methyl-1,2,5-oxadiazol-3-yl)oxy]ethyl]-4-nitroaniline
0
C-nitro compound00low000000
4-nitrocaramiphen
0
C-nitro compound00low000000
4-[(3-methyl-5-nitro-4-imidazolyl)amino]phenol
0
C-nitro compound;
imidazoles		00low000000
N-(2-methoxy-4-nitrophenyl)-2-[(1-methyl-2-imidazolyl)thio]acetamide
0
aromatic ether;
C-nitro compound		00low000000
N2-(3-methylphenyl)-6-(4-morpholinyl)-5-nitropyrimidine-2,4-diamine
0
C-nitro compound00low000000
sb 415286
0
C-nitro compound;
maleimides;
monochlorobenzenes;
phenols;
secondary amino compound;
substituted aniline		antioxidant;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
neuroprotective agent		00low000000
N-[3-(N-(2-chloro-1-oxoethyl)-4-nitroanilino)propyl]-2,2,2-trifluoroacetamide
0
C-nitro compound;
secondary carboxamide;
tertiary carboxamide;
trifluoroacetamide		00low000000
2-[[6-amino-2-[3-(dimethylamino)propylamino]-5-nitro-4-pyrimidinyl]amino]ethanol
0
C-nitro compound00low000000
4-(3-chlorophenyl)sulfonyl-N-cyclohexyl-N-methyl-3-nitrobenzamide
0
C-nitro compound00low000000
6-(2-methyl-1-piperidinyl)-5-nitro-4-pyrimidinamine
0
C-nitro compound00low000000
1-(5-nitro-2-thiophenyl)piperidine
0
C-nitro compound;
thiophenes		00low000000
N-[2-(2,4,6-trinitrophenyl)ethyl]aniline
0
C-nitro compound00low000000
2-nitro-4-phenylenediamine
0
C-nitro compound;
primary amino compound		00low000000
N2-(2-furanylmethyl)-5-nitro-6-(1-pyrrolidinyl)pyrimidine-2,4-diamine
0
C-nitro compound00low000000
1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)-2-[(6-methyl-2-nitro-3-pyridinyl)oxy]ethanone
0
C-nitro compound00low000000
N-(2-bromo-4-nitrophenyl)-2-[(5-propan-2-yl-1H-1,2,4-triazol-3-yl)thio]acetamide
0
C-nitro compound00low000000
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[(phenylmethyl)amino]ethyl] ester
0
C-nitro compound;
thiophenes		00low000000
2-(2,3-dihydroxypropylamino)-5-nitro-3-pyridinecarbonitrile
0
C-nitro compound00low000000
2-[(2-nitrophenyl)thio]-1-cyclooctanone
0
C-nitro compound00low000000
5-nitro-2-thiophenecarboxylic acid [2-oxo-2-[[oxo-[(phenylmethyl)amino]methyl]amino]ethyl] ester
0
C-nitro compound;
thiophenes		00low000000
N2-(2-furanylmethyl)-6-(3-methyl-1-piperidinyl)-5-nitropyrimidine-2,4-diamine
0
C-nitro compound00low000000
N'-(4-nitrophenyl)-9-oxo-3-bicyclo[3.3.1]nonanecarbohydrazide
0
C-nitro compound00low000000
alsterpaullone
0
C-nitro compound;
caprolactams;
organic heterotetracyclic compound		anti-HIV-1 agent;
antineoplastic agent;
apoptosis inducer;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor		00low000000
2-(4-fluoro-3-nitrophenyl)-4,4-dimethyl-5H-oxazole
0
C-nitro compound00low000000
1,2-diamino-4-nitrobenzene
0
C-nitro compound;
primary amino compound		00low000000
N'-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-4-nitrobenzohydrazide
0
C-nitro compound00low000000
furylfuramide
0
acrylamides;
C-nitro compound;
nitrofuran antibiotic;
primary carboxamide		00low000000
cilnidipine
0
2-methoxyethyl ester;
C-nitro compound;
dihydropyridine		antihypertensive agent;
calcium channel blocker;
cardiovascular drug		00low000000
ro 61-8048
0
C-nitro compound00low000000
meptyldinocap
0
C-nitro compound;
enoate ester		00low000000
l796778
0
benzenes;
C-nitro compound;
L-lysine derivative;
L-phenylalanine derivative;
methyl ester;
oligopeptide;
secondary carboxamide;
ureas		somatostatin receptor agonist00low000000
amocarzine
0
C-nitro compound;
N-methylpiperazine;
secondary amino compound;
thioureas		antinematodal drug00low000000
nitrovin
0
C-nitro compound;
furans		00low000000
dihydroxymethylfuratrizine
0
C-nitro compound;
furans		00low000000
nifurpirinol
0
C-nitro compound;
furans		00low000000
azanidazole
0
C-nitro compound;
imidazoles		00low000000
aureothin
0
4-pyranones;
C-nitro compound;
ketene acetal;
olefinic compound;
oxolanes		antibacterial agent;
antifungal agent;
antineoplastic agent;
antiparasitic agent;
bacterial metabolite;
EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor		00low000000
nidroxyzone
0
C-nitro compound;
furans		00low000000
nifurzide
0
C-nitro compound;
thiophenes		00low000000
abt-737
0
aromatic amine;
aryl sulfide;
biphenyls;
C-nitro compound;
monochlorobenzenes;
N-arylpiperazine;
N-sulfonylcarboxamide;
secondary amino compound;
tertiary amino compound		anti-allergic agent;
anti-inflammatory agent;
antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor		00low000000
5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine
0
1,3-thiazoles;
C-nitro compound;
organic sulfide;
primary amino compound;
thiadiazoles		antibacterial agent;
c-Jun N-terminal kinase inhibitor		00low000000
[4-(2-chlorophenyl)sulfonyl-3-nitrophenyl]-[4-(phenylmethyl)-1-piperazinyl]methanone
0
C-nitro compound00low000000
2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]thio]-N-(2-nitrophenyl)acetamide
0
C-nitro compound00low000000
2',3'-o-(2,4,6-trinitrophenyl)adenosine 5'-triphosphate
0
C-nitro compound;
spiroketal		antagonist00low000000
2-(4-morpholinyl)-N'-[(2-nitrophenyl)-oxomethyl]-4-thiazolecarbohydrazide
0
C-nitro compound00low000000
N'-[(2-methyl-3-nitrophenyl)-oxomethyl]-2-(4-morpholinyl)-4-thiazolecarbohydrazide
0
C-nitro compound00low000000
ML-210
0
C-nitro compound;
diarylmethane;
isoxazoles;
monochlorobenzenes;
N-acylpiperazine;
N-alkylpiperazine;
tertiary carboxamide		antineoplastic agent;
EC 1.11.1.9 (glutathione peroxidase) inhibitor;
ferroptosis inducer;
prodrug		00low000000
abt-199
0
aromatic ether;
C-nitro compound;
monochlorobenzenes;
N-alkylpiperazine;
N-arylpiperazine;
N-sulfonylcarboxamide;
oxanes;
pyrrolopyridine		antineoplastic agent;
apoptosis inducer;
B-cell lymphoma 2 inhibitor		00low000000
chir 98014
0
aminopyrimidine;
C-nitro compound;
diaminopyridine;
dichlorobenzene;
imidazoles;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
hypoglycemic agent;
tau aggregation inhibitor;
Wnt signalling activator		00low000000
acenocoumarol
0
C-nitro compound;
hydroxycoumarin;
methyl ketone		anticoagulant;
EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor		00low000000
8-nitroguanosine 3',5'-cyclic monophosphate
0
3',5'-cyclic purine nucleotide;
C-nitro compound		biomarker;
Brassica napus metabolite;
human metabolite;
signalling molecule		00low000000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100